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  • CRISPR-Based In Vivo Genome Editing and Base Editing

    CRISPR genome editing tools are driving innovations in precision genetic medicine. However, in vivo delivery of CRISPR components for treating diseases remains a challenge as researchers strive to eliminate or reduce off-target effects, provide transient editing systems, and incre…

  • Symptoms in ALS Mouse Model Improve with CRISPR Base Editing

    Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.

  • A New Lease on Life for shRNA

    Horizon Discovery describes how short hairpin RNA is advancing the development of chimeric antigen receptor T-cell therapies

  • COVID-19 Drives CRISPR Diagnostics

    Mammoth Biosciences is responding to the urgent need for improved and more accessible testing for COVID-19 by rapidly reconfiguring the company’s CRISPR-based diagnostics platform to detect the presence of SARS-CoV-2. In April, the company published a study demonstrating the pow…

  • MilliporeSigma Awarded 2 U.S. Patents toward CRISPR-Cas9-Assisted Genome Editing

    MilliporeSigma said it has been granted two U.S. patents toward CRISPR-Cas9-assisted genome-editing, the company's 25th and 26th CRISPR patents worldwide and third and fourth in the U.S. [Janet Iwasa for the Innovative Genomics Institute at UC Berkeley]

  • CRISPR Barcodes for Whole-Organism, Cell-by-Cell Lineage Histories

    Every organism has its own family tree. And like any family tree, an organism’s family tree is more interesting if it’s both complete and richly detailed. That is, each member of the family tree should be displayed in their proper place along with some biographical information…

  • Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa

    Despite being fundamentally important and having direct therapeutic implications, the functional genomics of the clinical isolates of multidrug-resistant (MDR) pathogens is often impeded by the lack of genome-editing tools. Here, we report the establishment of a highly efficient, …

  • Gene editing breakthrough allows precise fixes of humans and could destroy thousands of most deadly d

    A new gene-editing breakthrough allows scientists to easily snip out problems in genetic code, potentially removing thousands of deadly inherited diseases. The new technique could allow doctors to make changes to people's DNA and alter the molecular machines that help create us –…

  • HIV cure using gene editing shows promise in animal testing

    Researchers say they have removed HIV from the DNA of mice, an achievement the scientists say could be an early step towards an elusive cure for humans. The breakthrough, detailed earlier this week in a study credited to more than 30 scientists from Temple University and the Unive…