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  • Lysins Unlimited: Phages’ Secret Weapon

    It was 1917 when Felix d’Herelle, at the Institut Pasteur in Paris, first proposed using bacteriophages (or phages)—viruses that infect bacteria—as a therapy for human bacterial infections. Although used for decades in parts of Europe, notably Russia, Poland, and the Republi…

    2020-08-06
  • Cryo-EM Captures CRISPR-Cas9 Base Editor in Action

    CRISPR-Cas9’s ability to cut and edit DNA have long been the focus of the genome editing story. But CRISPR-Cas–guided base editors, that specifically correct a common class of base substitutions without cleaving DNA, have recently moved into the spotlight. In 2016, David Liu, …

    2020-08-05
  • First gene knockout in a cephalopod achieved

    A team at the Marine Biological Laboratory (MBL) has achieved the first gene knockout in a cephalopod using the squid Doryteuthis pealeii, an exceptionally important research organism in biology for nearly a century. The milestone study, led by MBL Senior Scientist Joshua Rosentha…

    2020-08-04
  • New understanding of CRISPR-Cas9 tool could improve gene editing

    Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic mutations responsible for hereditary diseases. Researc…

    2020-08-03
  • ENCODE Project Generates Registry of More Than One Million Human and Mouse Gene Regulatory Elements

    An online registry of over 1,200,000 human and mouse candidate functional elements that regulate genes has been generated as part of the third phase of the global ENCyclopedia of DNA Elements (ENCODE) project. The latest ENCODE findings, reported in a collection of 14 papers in Na…

    2020-07-31
  • Researchers map mechanisms in the largest CRISPR system

    The largest and most complex CRISPR system has been visualized by researchers from the University of Copenhagen in a new study. The system may have potential applications in biomedicine and biotechnology, the researchers believe. CRISPR technology can be used to edit genes and rev…

    2020-07-30
  • Site-directed mutagenesis in wheat via haploid induction by maize

    A new study, which has recently been published in the Plant Biotechnology Journal , demonstrates how site-directed mutagenesis can be achieved in virtually any wheat germplasm of choice by intergeneric pollination of wheat with cas9/guide-RNA (gRNA)-transgenic maize. For exemplifi…

    2020-07-29
  • New CRISPR C-to-G DNA base editor expands the landscape of precision genome editing

    New genome-editing technologies developed by researchers in J. Keith Joung's laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes. The ne…

    2020-07-28
  • Base editing is unquestionably one of the most exciting recent technology innovations in the field of

    Base editing is unquestionably one of the most exciting recent technology innovations in the field of genome editing. The development of these base editors in the lab of David Liu (Broad Institute/HHMI) enables the substitution of specific bases in DNA (C to T and A to G) without …

    2020-07-27