A team of collaborating Howard Hughes Medical Institute (HHMI) scientists has developed what they suggest is the first precision gene editing tool for mitochondrial DNA (mtDNA). The CRISPR-free technology exploits an interbacterial toxin—a kind of toxin that bacteria use to figh…
2020-07-14Using a CRISPR screen, scientists at the Salk Institute have discovered a genetic “dial” to turn immune function up and down. The scientists suggest that the dial, which affects the development and function of regulatory T cells (Tregs), could be turned one way to fight autoim…
2020-07-13Scientists at Duke University say they made the first time-lapse movies of the sheet-like latticework that surrounds and supports most animal tissues. A thin layer of extracellular matrix known as the basement membrane lines many surfaces of the body such as the skin, blood vessel…
2020-07-10CRISPR has become a household name largely because of its therapeutic promise, offering the potential for selectively and efficiently repairing genetic defects that contribute to diverse diseases. But in the research community, there is equal excitement about applying CRISPR-based…
2020-07-09Carpe diem, Horace’s famed proclamation, is usually translated as “seize the day.” A similar sentiment is embodied by a new method to detect RNA-binding proteins (RBPs) in living cells. It is called CARPID, which stands for CRISPR-Assisted RNA–Protein Interaction Detection…
2020-07-08Sherlovk Biosciences and binx health announced that the companies have entered a partnership to develop the world’s first point-of-care diagnostic test for COVID-19 leveraging CRISPR technology. The organizations will combine the binx io diagnostic platform with SHERLOCK TM CRIS…
2020-07-07Single-cell CRISPR screens enable the exploration of mammalian gene function and genetic regulatory networks. Recently, multiple techniques have emerged that pair CRISPR screens with high-throughput single-cell RNA sequencing (scRNA-seq), resulting in high resolution, information-…
2020-07-06Researchers have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused the diabetes…
2020-07-03White House officials have released guidelines to help states decide how — and when — to loosen social distancing measures in a way that prevents the coronavirus from surging back. But health experts say beginning to open parts of society during the pandemic hinges on the avai…
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