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  • CRISPR can push Pseudomonas aeruginosa into new horizon

    Extensive research has been focused to dissect the molecular basis of the infection mechanisms and to develop novel therapeutic means against P. aeruginosa infections. Meanwhile, P. aeruginosa represents a model organism for biological study of biofilm formation, quorum sensing, d…

  • Gene-editing RAW 264.7 cell line helps to study inflammation and osteoclast formation

    Murine macrophage cell line (RAW264.7) is considered to be one of the best models of macrophages, because it can carry out pinocytosis and phagocytosis, and is widely used in the study of inflammation, immunity, apoptosis and tumor. RAW264.7 cells can respond to stimulation in vit…

  • Knockout iPSC Cell line

    Many serious diseases cannot be cured by medicines, such as heart failure, Late Stage Diabetes, hemophilia, myeloma, End-Stage Cirrhosis, etc. The best method is allogeneic transplantation. However, due to the limited donors and the risk of immune rejection, researchers are dedica…

  • THP-1 Cell Line Gene-editing

    A human leukemic cell line (THP-1) cultured from the blood of a boy with acute monocytic leukemia. Since its establishment in 1980, THP-1 cells have been widely used in the research of monocyte and macrophage related mechanisms, signaling pathways, nutrient and drug transportation…

  • CircRNA Knockout Cell line

    circRNAs are circular noncoding RNAs formed by reverse splicing of pre-mRNAs. circRNAs were firstly found in viruses in the 1970s. However, due to the extensive use of the method for enrichment of poly (A) (no 5 'and 3' ends of circRNA) in the early RNA library preparation, …


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