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Ubigene has modified over 6000 genes from more than 300 cell lines with our exclusive innovation
CRISPR-U™ technology. At the same time, we already provide customers with high quality gene-editing
tools for cell or animal research worldwide.
With 15 years of experience, Ubigene has exclusively innovated and developed 6 product lines,
fullfilling all kinds of needs from researchers. Experiment process simplified, efficiency improved,
achieving our aim of 'Make genome editing easier'!
This project was initiated to construct the most resource rich and well-established gene KO resource bank worldwide, with the aim of providing superior resource sharing and more specialized technical services for basic research, drug R & D, disease diagnosis, treatment and evaluation in biomedical fields.
3 Essential Advantages Drive
In the next 3-5 years upon project initiation, to build up a KO cell line bank with 5,000 lines and the Red Cotton™gRNA Plasmid Bank with 25,000 gRNA plasmids
Red Cotton™ Gene Knockout Project
Red Cotton™ CRISPR Gene Editing System
Red Cotton™ CRISPR Gene Editing System
Red Cotton™CRISPR Gene Editing System, exclusively developed by Ubigene, is not only the platform to automatically design the CRISPR gene editing strategies, but also a high-throughput data processor with 3 data analysis systems. Based on two well-known databases, and by virtue of three major technical advantages: bioinformatics, IT and biotechnology, and the exclusive database with massive gene knockout success cases, Red Cotton™CRISPR Gene Editing System enables instantaneous deep integration and analysis of relevant parameters from over 100 types of cell lines and thousands of success cases, to generate 3 complete sets of gene knockout strategies within 1 min. The 3 data analysis systems, which is built by the professional IT team and bioinformatics team of Ubigene, is known as the perfect controller when generating a KO cell line. With functions of assessment of vector construction, high-throughput cell genotype analysis, and monoclonal target site validation, Red Cotton™CRISPR Gene Editing System constitutes a complete quality check for KO cell lines that guarantees high-standard quality control of knockout resources.Click here to get more information
High-throughput Plasmid Construction Platform
High-throughput Plasmid Construction Platform
The high-throughput Plasmid Construction Platform is the core of Ubigene Red Cotton™ gRNA Plasmid Bank, and the ability of high-throughput genome and transcriptome data analysis makes it maintain a steady plasmid construction, which guarantees the continuous high-quality expansion of Red Cotton™ gRNA Plasmid Bank, and is also a key step toward achieving a gene knockout.Click here to get more information
Ubigene-developed CRISPR-U™technology system
Ubigene-developed CRISPR-U™technology system
Ubigene has modified over 5000 genes from more than 100 cell lines with our developed efficient CRISPR-U™ technology. And CRISPR-U™ technology system is constituted with Ubigene’s CRISPR-U™technology and EZ-editor™Gene-editing Series Products. It ensures the CRISPR gene editing efficiency, and is the core technology to achieve the "Red Cotton™ Gene Knockout Project".
KO Cell Line Bank
Red Cotton™ gRNA Plasmid Bank
KO Cell Line Bank
5000+
We plan to expand the KO cell line resources of the KO cell line bank to 5000 within next 3-5 years
2021 Over 600 in-stock KO cells
2022 Over 2200 in-stock KO cells
2023 Over 3600 in-stock KO cells
By 2024 Over 5000 in-stock KO cells
The construction of KO cell line bank is a key project of Ubigene's "Red Cotton™ Gene Knockout Project". At present, we have preliminarily constructed a KO cell line bank, with more than 600 KO cell lines in-stock covering 10 research fields; We plan to expand the KO cell line resources of the KO cell line bank to 5000 within next 3-5 years.
To enable the KO Cell Line Bank has more promising applications, Ubigene combined bioinformatics technology with big data analysis technology to sort the cell lines and genes, and construct the customized KO cell line project with two main lines --signaling pathways and disease types:
Main Line 1 Signaling pathway research
8 popular signaling pathwaysnearly 900 genesover 1700 KO cell lines
In order to facilitate the research of signaling pathways, Ubigene has screened 8 popular signaling pathways including NF-kB, Hedgehog, JAK-STAT, MAPK, Notch, PI3K-Akt, TGF-beta, and Wnt and their relevant key genes (over 900 genes). We plan to construct more than 1700 KO cell lines.
Your gene is not in the list, please contact us to order the construction service.
Note: the gene list would be appropriately updated according to the research progress and research focus in each field.
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Route 2 Drug development
Screening of biological targets is the first stage for drug development. After target screening, it is necessary to establish a model for the evaluation of its effect. Generally, in vitro methods can be used to evaluate the activity at the molecular level, cell level or isolated organs, and then in vivo tests can be carried out on this basis. In order to assist the target verification in the process of drug R&D, Ubigene launched Gene Knockout Project with 11 fields of drug targets, covering nearly 400 genes.
All
antibody-drug conjugate
CAR-T
Tumor microenvironment
B7-CD28 family
Fc receptor
TNF family trimers
Transmembrane proteins
Adenylate pathway
Immune checkpoints (in vitro)
Immune checkpoints (in vivo)
Others
Type
Gene
Gene ID
Species
Main Line 2 Popular cells and genes
over 2700 KO cellsnearly 900 genescovering 100 diseases
In order to help with the research of disease discovery and treatment, we have screened 10 types of popular cell lines and nearly 900 genes, covering 8 human systems and nearly 100 diseases, and we plan to construct more than 2700 KO cell lines.
Human System
Respiratory system
Digestive system
Urinary system
Immune system
Endocrine system
Motor system
Reproductive system
Circulatory system
Other
Disease Type
Disease Type
Cell Line
HCT 116
THP-1
RAW 264.7
HepG2
System
Mental diseases
Endocrine diseases
Immune diseases
Infectious diseases
Genetic diseases
Cardiovascular diseases
Ear diseases
Bone diseases
Cancer diseases
Respiratory diseases
Reproductive diseases
Blood diseases
Metabolic diseases
Disease Type
Cell Line
HCT 116
THP-1
RAW 264.7
HepG2
Hela
4T1
Huh7
MC3T3
MDA-MB-231
U-87MG
Gene
Gene ID
Note: the gene list would be appropriately updated according to the research progress and research focus in each field.
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gRNA Plasmid Bank
25,000+
scale of KO cell bank to achieve the goal of ＞25000 gRNA plasmids within next 3-5 years.
2021 Over 10000 gRNA plasmids in-stock
2022 Over 15000 gRNA plasmids in-stock
2023 Over 20000 gRNA plasmids in-stock
By 2024 Over 25000 gRNA plasmids in-stock
As the basis of the "Red Cotton™ Gene Knockout Project", the Red Cotton™ gRNA Plasmid Bank has more than 10000 gRNA KO plasmids, and will continue to expand the scale of KO cell bank to achieve the goal of ＞25000 gRNA plasmids within next 3-5 years.
Based on our CRISPR-U™ Technology and thousands of gene-editing success cases, Ubigene has successfully developed a series of gRNA plasmids with high gene-editing efficiency. Ubigene's plasmids can enter cells via regular transfection methods and can edit target sites efficiently after transient expression of high levels of Cas9 protein in target cells. Also, our plasmids can be co-transfected with a variety of gRNAs to target multiple sites in cells, which can be widely used in different fields of gene-editing research.
Ubigene, make genome editing easier
Red Cotton™ CRISPR Gene Editing Designer
Ubigene's Red Cotton™ CRISPR Gene Editing Designer has been used more than 40000 times, which successfully designed more than 30000 CRISPR gene KO strategies, and our Red Cotton™CRISPR Gene Editing Designer has successfully solved problems for thousands of researchers.
Ubigene has successfully modified over 5000 genes from more than 100 cell lines with our developed CRISPR-U™ technology, and the KO efficiency leaps to 80%, and has higher homologous recombination efficiency. It can easily complete KO, point mutation and KI.
With 12 years of experience, Ubigene has exclusively innovated and developed 6 product lines, including Monoclone Validation Kit (extraction free), Wild-type Cell Lines, Stable Cell Lines (Cas9, Luciferase), Transfection Culture Medium, Over 10,000 in-stock gRNA plasmids, Cas9/GFP/mCherry/Luciferase expression Lentivirus, Mycoplasma Treatment Kit, which fully covers the experiment process of gene-editing in order to simplify the experiment process and improve the efficiency of gene-editing. Make genome editing easier!
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Gene Editing Services
EZ-editor™
Red Cotton Gene knockout Project
