Gene Knockout Cell Line Bank

NF-κB is a transcription factor widely existing in mammalian cells. As a key factor, it can bind to specific sites of promoter or enhancer sequences of a variety of genes to promote gene transcription and expression. NF-κB signaling pathway can regulate cell apoptosis, cell adhesion, cell proliferation, natural and adaptive immune response, inflammation, intracellular stress response and tissue remodeling, and so on. The activity of NF-κB is strictly and precisely regulated. NF-κB is a transcription factor that is maintained by many factors. Only by strictly maintaining this balance can cells survive and exercise their physiological functions normally. The study found that NF-κB is continuously activated in some diseases. While in other autoimmune diseases, it was found that the activity of NF-κB decreased. Which saying, once this balance is disrupted, excessive activation or inhibition will lead to physiological dysfunction and diseases, such as rheumatoid arthritis, atherosclerosis, multiple sclerosis and asthma, as well as a variety of cancers such as prostate cancer, glioma and lymphatic cancer.